Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer

A polymorphism in hMSH2 gene has been associated with an increased susceptibility to develop colorectal cancer (CRC). Here we show that it is a genetic risk factor for CRC in the Spanish population. However, its presence does not apparently affect hMSH2 function. © 2000 Cancer Research Campaign

Detalles Bibliográficos
Autores principales: Palicio, M, Blanco, I, Tórtola, S, González, I, Marcuello, E, Brunet, J, Lluis, F, González-Aguilera, J J, Peinado, M A, Capella, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363304/
https://www.ncbi.nlm.nih.gov/pubmed/10682661
http://dx.doi.org/10.1054/bjoc.1999.0959
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author Palicio, M
Blanco, I
Tórtola, S
González, I
Marcuello, E
Brunet, J
Lluis, F
González-Aguilera, J J
Peinado, M A
Capella, G
author_facet Palicio, M
Blanco, I
Tórtola, S
González, I
Marcuello, E
Brunet, J
Lluis, F
González-Aguilera, J J
Peinado, M A
Capella, G
author_sort Palicio, M
collection PubMed
description A polymorphism in hMSH2 gene has been associated with an increased susceptibility to develop colorectal cancer (CRC). Here we show that it is a genetic risk factor for CRC in the Spanish population. However, its presence does not apparently affect hMSH2 function. © 2000 Cancer Research Campaign
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spelling pubmed-23633042009-09-10 Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer Palicio, M Blanco, I Tórtola, S González, I Marcuello, E Brunet, J Lluis, F González-Aguilera, J J Peinado, M A Capella, G Br J Cancer Regular Article A polymorphism in hMSH2 gene has been associated with an increased susceptibility to develop colorectal cancer (CRC). Here we show that it is a genetic risk factor for CRC in the Spanish population. However, its presence does not apparently affect hMSH2 function. © 2000 Cancer Research Campaign Nature Publishing Group 2000-02 2000-01-18 /pmc/articles/PMC2363304/ /pubmed/10682661 http://dx.doi.org/10.1054/bjoc.1999.0959 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Palicio, M
Blanco, I
Tórtola, S
González, I
Marcuello, E
Brunet, J
Lluis, F
González-Aguilera, J J
Peinado, M A
Capella, G
Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title_full Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title_fullStr Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title_full_unstemmed Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title_short Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
title_sort intron splice acceptor site polymorphism in the hmsh2 gene in sporadic and familial colorectal cancer
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363304/
https://www.ncbi.nlm.nih.gov/pubmed/10682661
http://dx.doi.org/10.1054/bjoc.1999.0959
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