Cargando…

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

We analysed p16 gene alteration and p16, cyclin-dependent kinase 4 (CDK4), CDK6, cyclin D1, cyclin D2, cyclin D3 and retinoblastoma protein (pRb) expression in ten normal endometriums (PE), 18 endometrial hyperplasias (EH) and 35 endometrial cancers (EC). Two of ten PE (20%), nine of 18 EH (50.0%) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsuda, H, Yamamoto, K, Inoue, T, Uchiyama, I, Umesaki, N
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363310/ https://www.ncbi.nlm.nih.gov/pubmed/10682682 http://dx.doi.org/10.1054/bjoc.1999.0980

Ejemplares similares

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.
por: Maelandsmo, G. M., et al.
Publicado: (1996)

Expression of pRb, p53, p16 and Cyclin D1 and Their Clinical Implications in Urothelial Carcinoma
por: Lee, Kyungji, et al.
Publicado: (2010)

Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67
por: Tut, V M, et al.
Publicado: (2001)

CDK4, pRB and E2F1: connected to insulin
por: Fajas, Lluis, et al.
Publicado: (2010)

Loss of functional pRB is not a ubiquitous feature of B-cell malignancies
por: Sinclair, A J, et al.
Publicado: (1999)

Cell cycle regulators p27 and pRb in lymphomas – correlation with histology and proliferative activity
por: Kiviniemi, M, et al.
Publicado: (2000)

p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma
por: Supsavhad, Wachiraphan, et al.
Publicado: (2016)

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma
por: Plath, Michaela, et al.
Publicado: (2018)

Relevance of pRB Loss in Human Malignancies
por: Mandigo, Amy C., et al.
Publicado: (2022)

Prediction of progression in pTa and pT1 bladder carcinomas with p53, p16 and pRb
por: Hitchings, A W, et al.
Publicado: (2004)

Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro
por: Schrage, Yvonne M, et al.
Publicado: (2009)

Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4/CyclinD1‐pRB‐E2F1 pathway
por: Wang, Jing, et al.
Publicado: (2023)

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
por: Veas-Pérez de Tudela, Miguel, et al.
Publicado: (2015)

Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
por: Uchida, Chiharu
Publicado: (2016)

Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21
por: Kazem, Siamaque, et al.
Publicado: (2014)

Simultaneous Analysis of the p16 Gene and Protein in Canine Lymphoma Cells and Their Correlation with pRb Phosphorylation
por: Maylina, Leni, et al.
Publicado: (2022)

Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN‐amplified retinoblastoma
por: Ewens, Kathryn G., et al.
Publicado: (2017)

Differential expression of cyclin D1, Ki-67, pRb, and p53 in psoriatic skin lesions and normal skin
por: Kim, Sung Ae, et al.
Publicado: (2018)

Functional Ablation of pRb Activates Cdk2 and Causes Antiestrogen Resistance in Human Breast Cancer Cells
por: Varma, Hemant, et al.
Publicado: (2007)

Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner
por: Kim, Su-Jung, et al.
Publicado: (2023)

Antitumor mechanisms when pRb and p53 are genetically inactivated
por: Zhu, Liang, et al.
Publicado: (2014)

Treating cancer when pRb and p53 cannot be reactivated
por: Zhu, Liang
Publicado: (2015)

pRb or its cousins: Who controls the family business?
por: Itahana, Koji, et al.
Publicado: (2012)

Mutation of the LXCXE Binding Cleft of pRb Facilitates Transformation by ras In Vitro but Does Not Promote Tumorigenesis In Vivo
por: Talluri, Srikanth, et al.
Publicado: (2013)

Expression of Cell-Cycle Regulatory Proteins pRb, Cyclin D1, and p53 Is Not Associated with Recurrence Rates of Equine Sarcoids
por: Tura, Giorgia, et al.
Publicado: (2022)

p130 And pRb in the Maintenance of Transient Quiescence of Mesenchymal Stem Cells
por: Popov, Boris, et al.
Publicado: (2020)

pRb controls Estrogen Receptor alpha protein stability and activity
por: Caligiuri, Isabella, et al.
Publicado: (2013)

Pax6 Exerts Regional Control of Cortical Progenitor Proliferation via Direct Repression of Cdk6 and Hypophosphorylation of pRb
por: Mi, Da, et al.
Publicado: (2013)

pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation
por: Rozanska, Agata, et al.
Publicado: (2022)

Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines
por: Sartor, M, et al.
Publicado: (1999)

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
por: Haferkamp, Sebastian, et al.
Publicado: (2009)

Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7
por: Keijzers, Marlies, et al.
Publicado: (2015)

Aberrant Expression of pRb, p16, p14ARF, MDM2, p21 and p53 in Squamous Cell Carcinomas of Lung
por: Xue, Qi, et al.
Publicado: (2001)

Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors
por: Kim, Jin Hwan, et al.
Publicado: (2014)

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
por: Vietri, Michele, et al.
Publicado: (2006)

Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy
Publicado: (1995)

Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina
por: Nicolay, Brandon N., et al.
Publicado: (2010)

CENPA overexpression promotes genome instability in pRb-depleted human cells
por: Amato, Angela, et al.
Publicado: (2009)

Inhibition of pRB Pathway Differentially Modulates Apoptosis in Esophageal Cancer Cells
por: Soletti, Rossana C., et al.
Publicado: (2017)

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling
por: Buitrago-Pérez, Águeda, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_r9uggtdj4bnh89s3gmuvj8qakq