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Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent

β- D -Glucosyl-ifosfamide mustard (D 19575, glc-IPM, INN = glufosfamide) is a new agent for cancer chemotherapy. Its mode of action, which is only partly understood, was investigated at the DNA level. In the breast carcinoma cell line MCF7 glufosfamide inhibited both the synthesis of DNA and protein...

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Detalles Bibliográficos
Autores principales:	Seker, H, Bertram, B, Bürkle, A, Kaina, B, Pohl, J, Koepsell, H, Wießler, M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363326/ https://www.ncbi.nlm.nih.gov/pubmed/10682676 http://dx.doi.org/10.1054/bjoc.1999.0974

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