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Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene
Lobular carcinoma in situ (LCIS) is an unusual histological pattern of non-invasive neoplastic disease of the breast occurring predominantly in women aged between 40 and 50 years. LCIS is frequently multicentric and bilateral, and there is evidence that it is associated with an elevated familial ris...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363330/ https://www.ncbi.nlm.nih.gov/pubmed/10682667 http://dx.doi.org/10.1054/bjoc.1999.0965 |
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author | Rahman, N Stone, J G Coleman, G Gusterson, B Seal, S Marossy, A Lakhani, S R Ward, A Nash, A McKinna, A A'Hern, R Stratton, M R Houlston, R S |
author_facet | Rahman, N Stone, J G Coleman, G Gusterson, B Seal, S Marossy, A Lakhani, S R Ward, A Nash, A McKinna, A A'Hern, R Stratton, M R Houlston, R S |
author_sort | Rahman, N |
collection | PubMed |
description | Lobular carcinoma in situ (LCIS) is an unusual histological pattern of non-invasive neoplastic disease of the breast occurring predominantly in women aged between 40 and 50 years. LCIS is frequently multicentric and bilateral, and there is evidence that it is associated with an elevated familial risk of breast cancer. Although women with LCIS suffer an increased risk of invasive breast disease, this risk is moderate suggesting that LCIS may result from mutation of a gene or genes conferring a high risk of LCIS, but a lower risk of invasive breast cancer. The high frequency of somatic mutations in E-cadherin in LCIS, coupled with recent reports that germline mutations in this gene can predispose to diffuse gastric cancer, raised the possibility that constitutional E-cadherin mutations may confer susceptibility to LCIS. In order to explore this possibility we have examined a series of 65 LCIS patients for germline E-cadherin mutations. Four polymorphisms were detected but no pathogenic mutations were identified. The results indicate that E-cadherin is unlikely to act as a susceptibility gene for LCIS. © 2000 Cancer Research Campaign |
format | Text |
id | pubmed-2363330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23633302009-09-10 Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene Rahman, N Stone, J G Coleman, G Gusterson, B Seal, S Marossy, A Lakhani, S R Ward, A Nash, A McKinna, A A'Hern, R Stratton, M R Houlston, R S Br J Cancer Regular Article Lobular carcinoma in situ (LCIS) is an unusual histological pattern of non-invasive neoplastic disease of the breast occurring predominantly in women aged between 40 and 50 years. LCIS is frequently multicentric and bilateral, and there is evidence that it is associated with an elevated familial risk of breast cancer. Although women with LCIS suffer an increased risk of invasive breast disease, this risk is moderate suggesting that LCIS may result from mutation of a gene or genes conferring a high risk of LCIS, but a lower risk of invasive breast cancer. The high frequency of somatic mutations in E-cadherin in LCIS, coupled with recent reports that germline mutations in this gene can predispose to diffuse gastric cancer, raised the possibility that constitutional E-cadherin mutations may confer susceptibility to LCIS. In order to explore this possibility we have examined a series of 65 LCIS patients for germline E-cadherin mutations. Four polymorphisms were detected but no pathogenic mutations were identified. The results indicate that E-cadherin is unlikely to act as a susceptibility gene for LCIS. © 2000 Cancer Research Campaign Nature Publishing Group 2000-02 2000-01-18 /pmc/articles/PMC2363330/ /pubmed/10682667 http://dx.doi.org/10.1054/bjoc.1999.0965 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Rahman, N Stone, J G Coleman, G Gusterson, B Seal, S Marossy, A Lakhani, S R Ward, A Nash, A McKinna, A A'Hern, R Stratton, M R Houlston, R S Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title | Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title_full | Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title_fullStr | Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title_full_unstemmed | Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title_short | Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene |
title_sort | lobular carcinoma in situ of the breast is not caused by constitutional mutations in the e-cadherin gene |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363330/ https://www.ncbi.nlm.nih.gov/pubmed/10682667 http://dx.doi.org/10.1054/bjoc.1999.0965 |
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