Analysis of pilocytic astrocytoma by comparative genomic hybridization

Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed ab...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanoudou, D, Tingby, O, Ferguson-Smith, M A, Collins, V P, Coleman, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363345/
https://www.ncbi.nlm.nih.gov/pubmed/10735509
http://dx.doi.org/10.1054/bjoc.1999.1066
_version_ 1782153680869392384
author Sanoudou, D
Tingby, O
Ferguson-Smith, M A
Collins, V P
Coleman, N
author_facet Sanoudou, D
Tingby, O
Ferguson-Smith, M A
Collins, V P
Coleman, N
author_sort Sanoudou, D
collection PubMed
description Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed abnormalities detectable by comparative genomic hybridization, and in each case this represented gain of a single chromosome. Interestingly, two of seven tumours from adults showed abnormalities, which were multiple and relatively complex. Six of the seven tumours showing abnormalities were from female patients (two adults and four children). The most frequently detectable abnormality was gain of 9q34.1-qter, which was present in three cases (two adult and one paediatric). © 2000 Cancer Research Campaign
format Text
id pubmed-2363345
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23633452009-09-10 Analysis of pilocytic astrocytoma by comparative genomic hybridization Sanoudou, D Tingby, O Ferguson-Smith, M A Collins, V P Coleman, N Br J Cancer Short Communication Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed abnormalities detectable by comparative genomic hybridization, and in each case this represented gain of a single chromosome. Interestingly, two of seven tumours from adults showed abnormalities, which were multiple and relatively complex. Six of the seven tumours showing abnormalities were from female patients (two adults and four children). The most frequently detectable abnormality was gain of 9q34.1-qter, which was present in three cases (two adult and one paediatric). © 2000 Cancer Research Campaign Nature Publishing Group 2000-03 2000-02-21 /pmc/articles/PMC2363345/ /pubmed/10735509 http://dx.doi.org/10.1054/bjoc.1999.1066 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Sanoudou, D
Tingby, O
Ferguson-Smith, M A
Collins, V P
Coleman, N
Analysis of pilocytic astrocytoma by comparative genomic hybridization
title Analysis of pilocytic astrocytoma by comparative genomic hybridization
title_full Analysis of pilocytic astrocytoma by comparative genomic hybridization
title_fullStr Analysis of pilocytic astrocytoma by comparative genomic hybridization
title_full_unstemmed Analysis of pilocytic astrocytoma by comparative genomic hybridization
title_short Analysis of pilocytic astrocytoma by comparative genomic hybridization
title_sort analysis of pilocytic astrocytoma by comparative genomic hybridization
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363345/
https://www.ncbi.nlm.nih.gov/pubmed/10735509
http://dx.doi.org/10.1054/bjoc.1999.1066
work_keys_str_mv AT sanoudoud analysisofpilocyticastrocytomabycomparativegenomichybridization
AT tingbyo analysisofpilocyticastrocytomabycomparativegenomichybridization
AT fergusonsmithma analysisofpilocyticastrocytomabycomparativegenomichybridization
AT collinsvp analysisofpilocyticastrocytomabycomparativegenomichybridization
AT colemann analysisofpilocyticastrocytomabycomparativegenomichybridization

Ejemplares similares