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Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results
Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
2000
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363374/ https://www.ncbi.nlm.nih.gov/pubmed/10780514 http://dx.doi.org/10.1054/bjoc.1999.1077 |
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| author | Diel, I J Mundy, G R |
| author_facet | Diel, I J Mundy, G R |
| author_sort | Diel, I J |
| collection | PubMed |
| description | Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. © 2000 Cancer Research Campaign |
| format | Text |
| id | pubmed-2363374 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2000 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-23633742009-09-10 Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results Diel, I J Mundy, G R Br J Cancer Review Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy. © 2000 Cancer Research Campaign Nature Publishing Group 2000-04 2000-03-21 /pmc/articles/PMC2363374/ /pubmed/10780514 http://dx.doi.org/10.1054/bjoc.1999.1077 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Review Diel, I J Mundy, G R Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title | Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title_full | Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title_fullStr | Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title_full_unstemmed | Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title_short | Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| title_sort | bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363374/ https://www.ncbi.nlm.nih.gov/pubmed/10780514 http://dx.doi.org/10.1054/bjoc.1999.1077 |
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