Altered expression of members of the IGF-axis in hepatoblastomas

Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding norm...

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Autores principales: Gray, S G, Eriksson, T, Ekström, C, Holm, S, Schweinitz, D von, Kogner, P, Sandstedt, B, Pietsch, T, Ekstöm, T J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363389/
https://www.ncbi.nlm.nih.gov/pubmed/10789725
http://dx.doi.org/10.1054/bjoc.1999.1179
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author Gray, S G
Eriksson, T
Ekström, C
Holm, S
Schweinitz, D von
Kogner, P
Sandstedt, B
Pietsch, T
Ekstöm, T J
author_facet Gray, S G
Eriksson, T
Ekström, C
Holm, S
Schweinitz, D von
Kogner, P
Sandstedt, B
Pietsch, T
Ekstöm, T J
author_sort Gray, S G
collection PubMed
description Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development. © 2000 Cancer Research Campaign
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spelling pubmed-23633892009-09-10 Altered expression of members of the IGF-axis in hepatoblastomas Gray, S G Eriksson, T Ekström, C Holm, S Schweinitz, D von Kogner, P Sandstedt, B Pietsch, T Ekstöm, T J Br J Cancer Regular Article Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development. © 2000 Cancer Research Campaign Nature Publishing Group 2000-05 2000-04-03 /pmc/articles/PMC2363389/ /pubmed/10789725 http://dx.doi.org/10.1054/bjoc.1999.1179 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Gray, S G
Eriksson, T
Ekström, C
Holm, S
Schweinitz, D von
Kogner, P
Sandstedt, B
Pietsch, T
Ekstöm, T J
Altered expression of members of the IGF-axis in hepatoblastomas
title Altered expression of members of the IGF-axis in hepatoblastomas
title_full Altered expression of members of the IGF-axis in hepatoblastomas
title_fullStr Altered expression of members of the IGF-axis in hepatoblastomas
title_full_unstemmed Altered expression of members of the IGF-axis in hepatoblastomas
title_short Altered expression of members of the IGF-axis in hepatoblastomas
title_sort altered expression of members of the igf-axis in hepatoblastomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363389/
https://www.ncbi.nlm.nih.gov/pubmed/10789725
http://dx.doi.org/10.1054/bjoc.1999.1179
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