Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver

A phase I dose-escalation study was performed to determine whether isolated hepatic perfusion (IHP) with melphalan (L-PAM) allows exposure of the liver to much higher drug concentrations than clinically achievable after systemic administration and leads to higher tumour concentrations of L-PAM. Twen...

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Detalles Bibliográficos
Autores principales: Vahrmeijer, A L, van Dierendonck, J H, Keizer, H J, Beijnen, J H, Tollenaar, R A E M, Pijl, M E J, Marinelli, A, Kuppen, P J K, van Bockel, J H, Mulder, G J, Velde, C J H van de
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363396/
https://www.ncbi.nlm.nih.gov/pubmed/10789721
http://dx.doi.org/10.1054/bjoc.2000.1175

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