Screening breast cancer patients for Norwegian ATM mutations

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483 Norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (ATM) mutations previously found to account for 83% of the disease alleles in Norwegian ataxia telangiectasia (AT) patients. Only one carrier was found. These results provide no evidence in favour of a...

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Detalles Bibliográficos
Autores principales: Laake, K, Vu, P, Andersen, T I, Erikstein, B, Kåresen, R, Lønning, P E, Skovlund, E, Børresen-Dale, A L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363448/
https://www.ncbi.nlm.nih.gov/pubmed/11104561
http://dx.doi.org/10.1054/bjoc.2000.1519
Descripción
Sumario:483 Norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (ATM) mutations previously found to account for 83% of the disease alleles in Norwegian ataxia telangiectasia (AT) patients. Only one carrier was found. These results provide no evidence in favour of an excess risk of breast cancer associated with heterozygosity for classical AT mutations, but remain consistent with a maximum 2.4-fold increased risk. © 2000 Cancer Research Campaign http://www.bjcancer.com

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