Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more sig...

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Detalles Bibliográficos
Autores principales: Bader, S, Walker, M, Harrison, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363466/
https://www.ncbi.nlm.nih.gov/pubmed/11104560
http://dx.doi.org/10.1054/bjoc.2000.1482
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author Bader, S
Walker, M
Harrison, D
author_facet Bader, S
Walker, M
Harrison, D
author_sort Bader, S
collection PubMed
description The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported. © 2000 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23634662009-09-10 Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations Bader, S Walker, M Harrison, D Br J Cancer Short Communication The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported. © 2000 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2000-12 /pmc/articles/PMC2363466/ /pubmed/11104560 http://dx.doi.org/10.1054/bjoc.2000.1482 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Bader, S
Walker, M
Harrison, D
Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title_full Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title_fullStr Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title_full_unstemmed Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title_short Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
title_sort most microsatellite unstable sporadic colorectal carcinomas carry mbd4 mutations
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363466/
https://www.ncbi.nlm.nih.gov/pubmed/11104560
http://dx.doi.org/10.1054/bjoc.2000.1482
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AT harrisond mostmicrosatelliteunstablesporadiccolorectalcarcinomascarrymbd4mutations

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