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Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumours

CT-2584 HMS, 1-(11-dodecylamino-10-hydroxyundecyl)-3,7-dimethylxanthine-hydrogen methanesulphonate, is a modulator of intracellular phosphatidic acid. We treated 30 patients as part of a Phase I and pharmacokinetic study to determine the maximum-tolerated dose of CT-2584 HMS, toxicity profiles, phar...

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Detalles Bibliográficos
Autores principales:	Cheeseman, S L, Brannan, M, McGown, A, Khan, P, Gardner, C, Gumbrell, L, Dickens, D, Ranson, M
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363467/ https://www.ncbi.nlm.nih.gov/pubmed/11104552 http://dx.doi.org/10.1054/bjoc.2000.1503

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