Cargando…

Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha

Thymidine phosphorylase (TP) is an essential enzyme for the biochemical activation of 5-fluorouracil (5-FU). Interferon upregulates TP in vivo, although the dose and schedule of interferon for optimal biomodulation of 5-FU is not known. In this study, TP activity was measured in peripheral blood lym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braybrooke, J P, Propper, D J, O’Byrne, K J, Koukourakis, M I, Patterson, A V, Houlbrook, S, Love, S D, Varcoe, S, Taylor, M, Ganesan, T S, Talbot, D C, Harris, A L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2000
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363491/ https://www.ncbi.nlm.nih.gov/pubmed/10901374 http://dx.doi.org/10.1054/bjoc.2000.1230

Ejemplares similares

Cyclophosphamide, methotrexate and infusional 5-fluorouracil (infusional CMF) in metastatic breast cancer.
por: O'Byrne, K. J., et al.
Publicado: (1998)

Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in non-small-cell lung cancer: impact on tumour neoangiogenesis and survival.
por: Koukourakis, M. I., et al.
Publicado: (1998)

Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma
por: Lee, Lucas D., et al.
Publicado: (2022)

A possible role of thymidine phosphorylase expression and5-fluorouracil increased sensitivity in oropharyngeal cancer patients
por: Ranieri, G, et al.
Publicado: (2007)

Quantification of Plasma and Urine Thymidine and 2’-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy
por: Kipper, Karin, et al.
Publicado: (2020)

A phase II study of bryostatin 1 in metastatic malignant melanoma.
por: Propper, D. J., et al.
Publicado: (1998)

5-Fluorouracil and folinic acid: interesting biochemistry or effective treatment?
por: Kerr, D. J.
Publicado: (1989)

The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma
por: Saito, H, et al.
Publicado: (1999)

Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer
por: O'Byrne, K J, et al.
Publicado: (1999)

Phase II study of second-line therapy with DTIC, BCNU, cisplatin and tamoxifen (Dartmouth regimen) chemotherapy in patients with malignant melanoma previously treated with dacarbazine
por: Propper, D J, et al.
Publicado: (2000)

The cytosol activity of thymidine phosphorylase in endometrial cancer
por: Miszczak-Zaborska, Elżbieta, et al.
Publicado: (2008)

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma
por: Takebayashi, Yuji, et al.
Publicado: (1996)

Thymidine phosphorylase expression and prognosis in colorectal cancer treated with 5-fluorouracil-based chemotherapy: A meta-analysis
por: Che, Jia, et al.
Publicado: (2017)

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis
por: Sivridis, E, et al.
Publicado: (2002)

Increased cytotoxicity and bystander effect of 5-fluorouracil and 5′-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase
por: Evrard, A, et al.
Publicado: (1999)

Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis
por: Marchetti, S, et al.
Publicado: (2001)

Expression of the thymidine phosphorylase gene in epithelial ovarian cancer
por: Hata, K, et al.
Publicado: (1999)

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase
por: Di Gennaro, E, et al.
Publicado: (2010)

Safety and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase in Mitochondrial Neurogastrointestinal Encephalomyopathy
por: Levene, Michelle, et al.
Publicado: (2019)

Liver as a Source for Thymidine Phosphorylase Replacement in Mitochondrial Neurogastrointestinal Encephalomyopathy
por: Boschetti, Elisa, et al.
Publicado: (2014)

5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
por: Jebb, S. A., et al.
Publicado: (1994)

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
por: Patterson, A. V., et al.
Publicado: (1995)

Biochemical abnormalities in a patient with thymidine phosphorylase deficiency with fatal outcome
por: Bakker, Jaap A., et al.
Publicado: (2010)

Phase II study of the oxygen saturation curve left shifting agent BW12C in combination with the hypoxia activated drug mitomycin C in advanced colorectal cancer
por: Propper, D J, et al.
Publicado: (2000)

Interferon-α Enhances 5′-Deoxy-5-Fluorouridine-Induced Apoptosis by ERK-Dependant Upregulation of Thymidine Phosphorylase
por: Zhu, Yike, et al.
Publicado: (2013)

No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix
por: Kabuubi, P, et al.
Publicado: (2006)

Modulation of thymidine phosphorylase by neoadjuvant chemotherapy in primary breast cancer
por: Toi, M, et al.
Publicado: (2004)

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil
por: Mitsiki, Eirini, et al.
Publicado: (2009)

Thymidine Phosphorylase Gene Expression in Stage III Colorectal Cancer
por: Lindskog, Elinor B., et al.
Publicado: (2012)

Depletion of plasma thymidine results in growth retardation and mitochondrial myopathy in mice overexpressing human thymidine phosphorylase
por: Harada, Naomoto, et al.
Publicado: (2023)

Phase I trial of oxaliplatin with fluorouracil, folinic acid and concurrent radiotherapy for oesophageal cancer
por: Conroy, T, et al.
Publicado: (2008)

Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome
por: Nie, Xingcao, et al.
Publicado: (2011)

Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE
por: Meinders, Marjolein, et al.
Publicado: (2020)

The Expression of Thymidine Phosphorylase in Cancer-infiltrating Inflammatory Cells in Stomach Cancer
por: Jang, Joung Soon, et al.
Publicado: (2007)

Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma
por: Ye, Dian-Jun, et al.
Publicado: (2013)

Possible role of thymidine phosphorylase in gynecological tumors as an individualized treatment strategy
por: Shida, Masako, et al.
Publicado: (2016)

Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent Manner
por: Li, Wei, et al.
Publicado: (2021)

Adjuvant chemoradiotherapy of advanced resectable rectal cancer: results of a randomised trial comparing modulation of 5-fluorouracil with folinic acid or with interferon-α
por: Kornmann, M, et al.
Publicado: (2010)

Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin
por: Gonzalez, M A, et al.
Publicado: (2003)

Fluorouracil/folinic acid/oxaliplatin: Various toxicities: 2 case reports
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6hv5pice3kbch159pj702d92dr