Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2

Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumo...

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Autores principales: Rapley, E A, Barfoot, R, Bonaïti-Pellié, C, Chompret, A, Foulkes, W, Perusinghe, N, Reeve, A, Royer-Pokora, B, Schumacher, V, Shelling, A, Skeen, J, Tourreil, S de, Weirich, A, Pritchard-Jones, K, Stratton, M R, Rahman, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363495/
https://www.ncbi.nlm.nih.gov/pubmed/10901367
http://dx.doi.org/10.1054/bjoc.2000.1283
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author Rapley, E A
Barfoot, R
Bonaïti-Pellié, C
Chompret, A
Foulkes, W
Perusinghe, N
Reeve, A
Royer-Pokora, B
Schumacher, V
Shelling, A
Skeen, J
Tourreil, S de
Weirich, A
Pritchard-Jones, K
Stratton, M R
Rahman, N
author_facet Rapley, E A
Barfoot, R
Bonaïti-Pellié, C
Chompret, A
Foulkes, W
Perusinghe, N
Reeve, A
Royer-Pokora, B
Schumacher, V
Shelling, A
Skeen, J
Tourreil, S de
Weirich, A
Pritchard-Jones, K
Stratton, M R
Rahman, N
author_sort Rapley, E A
collection PubMed
description Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found. © 2000 Cancer Research Campaign
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spelling pubmed-23634952009-09-10 Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2 Rapley, E A Barfoot, R Bonaïti-Pellié, C Chompret, A Foulkes, W Perusinghe, N Reeve, A Royer-Pokora, B Schumacher, V Shelling, A Skeen, J Tourreil, S de Weirich, A Pritchard-Jones, K Stratton, M R Rahman, N Br J Cancer Regular Article Three loci have been implicated in familial Wilms tumour: WT1 located on chromosome 11p13, FWT1 on 17q12-q21, and FWT2 on 19q13. Two out of 19 Wilms tumour families evaluated showed strong evidence against linkage at all three loci. Both of these families contained at least three cases of Wilms tumour indicating that they were highly likely to be due to genetic susceptibility and therefore that one or more additional familial Wilms tumour susceptibility genes remain to be found. © 2000 Cancer Research Campaign Nature Publishing Group 2000-07 2000-06-15 /pmc/articles/PMC2363495/ /pubmed/10901367 http://dx.doi.org/10.1054/bjoc.2000.1283 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Rapley, E A
Barfoot, R
Bonaïti-Pellié, C
Chompret, A
Foulkes, W
Perusinghe, N
Reeve, A
Royer-Pokora, B
Schumacher, V
Shelling, A
Skeen, J
Tourreil, S de
Weirich, A
Pritchard-Jones, K
Stratton, M R
Rahman, N
Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title_full Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title_fullStr Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title_full_unstemmed Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title_short Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
title_sort evidence for susceptibility genes to familial wilms tumour in addition to wt1, fwt1 and fwt2
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363495/
https://www.ncbi.nlm.nih.gov/pubmed/10901367
http://dx.doi.org/10.1054/bjoc.2000.1283
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