The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study

The aims of the UKW2 study were: (1) to further refine treatment for stage I and II favourable histology (FH) patients; (2) to consolidate the UKW1 results for stage III FH patients; (3) to improve the outlook for patients with inoperable primary tumours and those patients with stage IV and unfavour...

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Autores principales: Mitchell, C, Jones, P Morris, Kelsey, A, Vujanic, G M, Marsden, B, Shannon, R, Gornall, P, Owens, C, Taylor, R, Imeson, J, Middleton, H, Pritchard, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363501/
https://www.ncbi.nlm.nih.gov/pubmed/10944599
http://dx.doi.org/10.1054/bjoc.2000.1338
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author Mitchell, C
Jones, P Morris
Kelsey, A
Vujanic, G M
Marsden, B
Shannon, R
Gornall, P
Owens, C
Taylor, R
Imeson, J
Middleton, H
Pritchard, J
author_facet Mitchell, C
Jones, P Morris
Kelsey, A
Vujanic, G M
Marsden, B
Shannon, R
Gornall, P
Owens, C
Taylor, R
Imeson, J
Middleton, H
Pritchard, J
author_sort Mitchell, C
collection PubMed
description The aims of the UKW2 study were: (1) to further refine treatment for stage I and II favourable histology (FH) patients; (2) to consolidate the UKW1 results for stage III FH patients; (3) to improve the outlook for patients with inoperable primary tumours and those patients with stage IV and unfavourable histology disease. Treatment consisted of primary nephrectomy, wherever possible, followed by chemotherapy and radiotherapy, as dictated by stage and histology. Treatment was refined successfully for stage I and II FH patients. The 4-year event-free survival for these two groups was 94% and 91%, respectively. Stage III FH patients had a 4-year event free survival of 84%. The outlook for patients with clear cell sarcoma of the kidney is as good as for patients with favourable histology, whilst that for patients with anaplastic or rhabdoid variants remains poor. The outlook for the majority of children with Wilms’ tumour is now excellent. © 2000 Cancer Research Campaign
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spelling pubmed-23635012009-09-10 The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study Mitchell, C Jones, P Morris Kelsey, A Vujanic, G M Marsden, B Shannon, R Gornall, P Owens, C Taylor, R Imeson, J Middleton, H Pritchard, J Br J Cancer Regular Article The aims of the UKW2 study were: (1) to further refine treatment for stage I and II favourable histology (FH) patients; (2) to consolidate the UKW1 results for stage III FH patients; (3) to improve the outlook for patients with inoperable primary tumours and those patients with stage IV and unfavourable histology disease. Treatment consisted of primary nephrectomy, wherever possible, followed by chemotherapy and radiotherapy, as dictated by stage and histology. Treatment was refined successfully for stage I and II FH patients. The 4-year event-free survival for these two groups was 94% and 91%, respectively. Stage III FH patients had a 4-year event free survival of 84%. The outlook for patients with clear cell sarcoma of the kidney is as good as for patients with favourable histology, whilst that for patients with anaplastic or rhabdoid variants remains poor. The outlook for the majority of children with Wilms’ tumour is now excellent. © 2000 Cancer Research Campaign Nature Publishing Group 2000-09 2000-08-16 /pmc/articles/PMC2363501/ /pubmed/10944599 http://dx.doi.org/10.1054/bjoc.2000.1338 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Mitchell, C
Jones, P Morris
Kelsey, A
Vujanic, G M
Marsden, B
Shannon, R
Gornall, P
Owens, C
Taylor, R
Imeson, J
Middleton, H
Pritchard, J
The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title_full The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title_fullStr The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title_full_unstemmed The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title_short The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study
title_sort treatment of wilms' tumour: results of the united kingdom children's cancer study group (ukccsg) second wilms' tumour study
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363501/
https://www.ncbi.nlm.nih.gov/pubmed/10944599
http://dx.doi.org/10.1054/bjoc.2000.1338
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