Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cellines

We have used serial analysis of gene expression (SAGE) to identify gene expression differences between a primary colon tumour cell line (SW480) and an isogenic lymph-node metastasis cell line (SW620). Differential expression was confirmed for the following genes: keratin K5, cystatin S, serum amyloi...

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Detalles Bibliográficos
Autores principales: Parle-McDermott, A, McWilliam, P, Tighe, O, Dunican, D, Croke, D T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363537/
https://www.ncbi.nlm.nih.gov/pubmed/10952775
http://dx.doi.org/10.1054/bjoc.2000.1330
Descripción
Sumario:We have used serial analysis of gene expression (SAGE) to identify gene expression differences between a primary colon tumour cell line (SW480) and an isogenic lymph-node metastasis cell line (SW620). Differential expression was confirmed for the following genes: keratin K5, cystatin S, serum amyloid A, the human homologue of yeast ribosomal S28 and the p32 subunit of human pre-mRNA splicing factor SF2. Expression of confirmed differences were also analysed in other metastatic cell lines. © 2000 Cancer Research Campaign

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