P21-dependent G (1) arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

Depsipeptide, FR901228, a novel cyclic peptide inhibitor of histone deacetylase with a unique cytotoxicity profile is currently in phase I clinical trials. Here we demonstrate that, in addition to G2/M arrest, FR901228 causes G1 arrest with Rb hypophosphorylation. In vitro kinase assays demonstrated...

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Detalles Bibliográficos
Autores principales: Sandor, V, Senderowicz, A, Mertins, S, Sackett, D, Sausville, E, Blagosklonny, M V, Bates, S E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363539/
https://www.ncbi.nlm.nih.gov/pubmed/10952788
http://dx.doi.org/10.1054/bjoc.2000.1327

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