Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331

Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. dUTPase catalyses the hydrolysis of dUTP to dUMP, thereby maintaining low intracellular dUTP. We have addressed the relationship between dUTPase expression and...

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Detalles Bibliográficos
Autores principales: Webley, S D, Hardcastle, A, Ladner, R D, Jackman, A L, Aherne, G W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363540/
https://www.ncbi.nlm.nih.gov/pubmed/10952785
http://dx.doi.org/10.1054/bjoc.2000.1358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363540/
https://www.ncbi.nlm.nih.gov/pubmed/10952785
http://dx.doi.org/10.1054/bjoc.2000.1358

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