Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas

Hepatoblastoma is a malignant paediatric liver tumour. In order to approach the genetic background of this malignancy we have screened a panel of eighteen cases from Europe and Japan for chromosomal imbalances using comparative genomic hybridization (CGH). The most frequent losses included chromosom...

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Autores principales: Gray, S G, Kytölä, S, Matsunaga, T, Larsson, C, Ekström, T J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363571/
https://www.ncbi.nlm.nih.gov/pubmed/10993649
http://dx.doi.org/10.1054/bjoc.2000.1390
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author Gray, S G
Kytölä, S
Matsunaga, T
Larsson, C
Ekström, T J
author_facet Gray, S G
Kytölä, S
Matsunaga, T
Larsson, C
Ekström, T J
author_sort Gray, S G
collection PubMed
description Hepatoblastoma is a malignant paediatric liver tumour. In order to approach the genetic background of this malignancy we have screened a panel of eighteen cases from Europe and Japan for chromosomal imbalances using comparative genomic hybridization (CGH). The most frequent losses included chromosomal regions 13q21–q22 (28%) and 9p22-pter (22%), while the most frequent gains occurred on 2q23–q24 (33%), 20q (28%) and 1q24–q25 (28%). A significant difference in CGH alterations between the tumours from patients of Caucasian and Japanese was revealed where loss of 13q was found only in the Japanese samples. In conclusion, the findings indicate several candidate regions for suppressor genes and oncogenes potentially involved in the hepatoblastomas of different ethnic origin. © 2000 Cancer Research Campaign
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spelling pubmed-23635712009-09-10 Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas Gray, S G Kytölä, S Matsunaga, T Larsson, C Ekström, T J Br J Cancer Regular Article Hepatoblastoma is a malignant paediatric liver tumour. In order to approach the genetic background of this malignancy we have screened a panel of eighteen cases from Europe and Japan for chromosomal imbalances using comparative genomic hybridization (CGH). The most frequent losses included chromosomal regions 13q21–q22 (28%) and 9p22-pter (22%), while the most frequent gains occurred on 2q23–q24 (33%), 20q (28%) and 1q24–q25 (28%). A significant difference in CGH alterations between the tumours from patients of Caucasian and Japanese was revealed where loss of 13q was found only in the Japanese samples. In conclusion, the findings indicate several candidate regions for suppressor genes and oncogenes potentially involved in the hepatoblastomas of different ethnic origin. © 2000 Cancer Research Campaign Nature Publishing Group 2000-10 /pmc/articles/PMC2363571/ /pubmed/10993649 http://dx.doi.org/10.1054/bjoc.2000.1390 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Gray, S G
Kytölä, S
Matsunaga, T
Larsson, C
Ekström, T J
Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title_full Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title_fullStr Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title_full_unstemmed Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title_short Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
title_sort comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363571/
https://www.ncbi.nlm.nih.gov/pubmed/10993649
http://dx.doi.org/10.1054/bjoc.2000.1390
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