A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy

One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown...

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Detalles Bibliográficos
Autores principales: Kohler, J A, Imeson, J, Ellershaw, C, Lie, S O
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363577/
https://www.ncbi.nlm.nih.gov/pubmed/11027423
http://dx.doi.org/10.1054/bjoc.2000.1425
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author Kohler, J A
Imeson, J
Ellershaw, C
Lie, S O
author_facet Kohler, J A
Imeson, J
Ellershaw, C
Lie, S O
author_sort Kohler, J A
collection PubMed
description One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid. © 2000 Cancer Research Campaign
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spelling pubmed-23635772009-09-10 A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy Kohler, J A Imeson, J Ellershaw, C Lie, S O Br J Cancer Regular Article One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid. © 2000 Cancer Research Campaign Nature Publishing Group 2000-11 /pmc/articles/PMC2363577/ /pubmed/11027423 http://dx.doi.org/10.1054/bjoc.2000.1425 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Kohler, J A
Imeson, J
Ellershaw, C
Lie, S O
A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title_full A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title_fullStr A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title_full_unstemmed A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title_short A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
title_sort randomized trial of 13-cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363577/
https://www.ncbi.nlm.nih.gov/pubmed/11027423
http://dx.doi.org/10.1054/bjoc.2000.1425
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