Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States

To test the hypothesis that in utero exposure to high levels of oestrogen increases the risk of male breast cancer, we followed 115 235 male twins for more than 3.5 million person-years at risk. We observed 11 cases of male breast cancer versus 16.16 expected based on national rates (standardized ra...

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Autores principales: Whiteman, D C, Murphy, M F G, Verkasalo, P K, Page, W F, Floderus, B, Skytthe, A, Holm, N V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363585/
https://www.ncbi.nlm.nih.gov/pubmed/11027438
http://dx.doi.org/10.1054/bjoc.2000.1468
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author Whiteman, D C
Murphy, M F G
Verkasalo, P K
Page, W F
Floderus, B
Skytthe, A
Holm, N V
author_facet Whiteman, D C
Murphy, M F G
Verkasalo, P K
Page, W F
Floderus, B
Skytthe, A
Holm, N V
author_sort Whiteman, D C
collection PubMed
description To test the hypothesis that in utero exposure to high levels of oestrogen increases the risk of male breast cancer, we followed 115 235 male twins for more than 3.5 million person-years at risk. We observed 11 cases of male breast cancer versus 16.16 expected based on national rates (standardized rate ratio 0.68, 95% confidence interval 0.34–1.22) and conclude that any adverse influence of in utero oestrogen exposure is likely to be small. © 2000 Cancer Research Campaign
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spelling pubmed-23635852009-09-10 Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States Whiteman, D C Murphy, M F G Verkasalo, P K Page, W F Floderus, B Skytthe, A Holm, N V Br J Cancer Short Communication To test the hypothesis that in utero exposure to high levels of oestrogen increases the risk of male breast cancer, we followed 115 235 male twins for more than 3.5 million person-years at risk. We observed 11 cases of male breast cancer versus 16.16 expected based on national rates (standardized rate ratio 0.68, 95% confidence interval 0.34–1.22) and conclude that any adverse influence of in utero oestrogen exposure is likely to be small. © 2000 Cancer Research Campaign Nature Publishing Group 2000-11 /pmc/articles/PMC2363585/ /pubmed/11027438 http://dx.doi.org/10.1054/bjoc.2000.1468 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Whiteman, D C
Murphy, M F G
Verkasalo, P K
Page, W F
Floderus, B
Skytthe, A
Holm, N V
Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title_full Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title_fullStr Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title_full_unstemmed Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title_short Breast cancer risk in male twins: joint analyses of four twin cohorts in Denmark, Finland, Sweden and the United States
title_sort breast cancer risk in male twins: joint analyses of four twin cohorts in denmark, finland, sweden and the united states
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363585/
https://www.ncbi.nlm.nih.gov/pubmed/11027438
http://dx.doi.org/10.1054/bjoc.2000.1468
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