Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice

Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a...

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Autores principales: Parnaud, G, Taché, S, Peiffer, G, Corpet, D E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363619/
https://www.ncbi.nlm.nih.gov/pubmed/11139319
http://dx.doi.org/10.1054/bjoc.2000.1540
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author Parnaud, G
Taché, S
Peiffer, G
Corpet, D E
author_facet Parnaud, G
Taché, S
Peiffer, G
Corpet, D E
author_sort Parnaud, G
collection PubMed
description Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636192008-08-29 Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice Parnaud, G Taché, S Peiffer, G Corpet, D E Br J Cancer Short Communication Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-01 2001-01-01 /pmc/articles/PMC2363619/ /pubmed/11139319 http://dx.doi.org/10.1054/bjoc.2000.1540 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Parnaud, G
Taché, S
Peiffer, G
Corpet, D E
Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title_full Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title_fullStr Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title_full_unstemmed Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title_short Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
title_sort pluronic f68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363619/
https://www.ncbi.nlm.nih.gov/pubmed/11139319
http://dx.doi.org/10.1054/bjoc.2000.1540
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AT corpetde pluronicf68blockpolymeraverypotentsuppressorofcarcinogenesisinthecolonofratsandmice

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