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Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2001
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363635/ https://www.ncbi.nlm.nih.gov/pubmed/11355941 http://dx.doi.org/10.1054/bjoc.2001.1790 |
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author | Masaki, T Matsuoka, H Sugiyama, M Abe, N Goto, A Sakamoto, A Atomi, Y |
author_facet | Masaki, T Matsuoka, H Sugiyama, M Abe, N Goto, A Sakamoto, A Atomi, Y |
author_sort | Masaki, T |
collection | PubMed |
description | Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. 38 early invasive colorectal carcinomas treated by local excision or radical surgery were examined. Tumour budding was evaluated as the number of dedifferentiation units along the entire invasive margin. Matrilysin protein levels were determined using immunohistochemical study. Univariate analysis showed that matrilysin expression alone was significantly associated with distant metastasis (P= 0.0339), and both tumour budding and matrilysin expression were significantly associated with adverse outcome (P= 0.0005, 0.0341). Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with either distant metastasis or adverse outcome. Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcome, although the significance of matrilysin expression was marginal (P= 0.0488). Tumour budding at the invasive margin and matrilysin expression are more useful in identifying high-risk groups for adverse outcome in patients with early invasive colorectal carcinomas. © 2001 Cancer Research Campaign www.bjcancer.com |
format | Text |
id | pubmed-2363635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23636352009-09-10 Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas Masaki, T Matsuoka, H Sugiyama, M Abe, N Goto, A Sakamoto, A Atomi, Y Br J Cancer Regular Article Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. 38 early invasive colorectal carcinomas treated by local excision or radical surgery were examined. Tumour budding was evaluated as the number of dedifferentiation units along the entire invasive margin. Matrilysin protein levels were determined using immunohistochemical study. Univariate analysis showed that matrilysin expression alone was significantly associated with distant metastasis (P= 0.0339), and both tumour budding and matrilysin expression were significantly associated with adverse outcome (P= 0.0005, 0.0341). Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with either distant metastasis or adverse outcome. Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcome, although the significance of matrilysin expression was marginal (P= 0.0488). Tumour budding at the invasive margin and matrilysin expression are more useful in identifying high-risk groups for adverse outcome in patients with early invasive colorectal carcinomas. © 2001 Cancer Research Campaign www.bjcancer.com Nature Publishing Group 2001-05 /pmc/articles/PMC2363635/ /pubmed/11355941 http://dx.doi.org/10.1054/bjoc.2001.1790 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Masaki, T Matsuoka, H Sugiyama, M Abe, N Goto, A Sakamoto, A Atomi, Y Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title | Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title_full | Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title_fullStr | Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title_full_unstemmed | Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title_short | Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
title_sort | matrilysin (mmp-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363635/ https://www.ncbi.nlm.nih.gov/pubmed/11355941 http://dx.doi.org/10.1054/bjoc.2001.1790 |
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