Cargando…

Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas

Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken...

Descripción completa

Detalles Bibliográficos
Autores principales: Masaki, T, Matsuoka, H, Sugiyama, M, Abe, N, Goto, A, Sakamoto, A, Atomi, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363635/
https://www.ncbi.nlm.nih.gov/pubmed/11355941
http://dx.doi.org/10.1054/bjoc.2001.1790
_version_ 1782153753768493056
author Masaki, T
Matsuoka, H
Sugiyama, M
Abe, N
Goto, A
Sakamoto, A
Atomi, Y
author_facet Masaki, T
Matsuoka, H
Sugiyama, M
Abe, N
Goto, A
Sakamoto, A
Atomi, Y
author_sort Masaki, T
collection PubMed
description Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. 38 early invasive colorectal carcinomas treated by local excision or radical surgery were examined. Tumour budding was evaluated as the number of dedifferentiation units along the entire invasive margin. Matrilysin protein levels were determined using immunohistochemical study. Univariate analysis showed that matrilysin expression alone was significantly associated with distant metastasis (P= 0.0339), and both tumour budding and matrilysin expression were significantly associated with adverse outcome (P= 0.0005, 0.0341). Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with either distant metastasis or adverse outcome. Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcome, although the significance of matrilysin expression was marginal (P= 0.0488). Tumour budding at the invasive margin and matrilysin expression are more useful in identifying high-risk groups for adverse outcome in patients with early invasive colorectal carcinomas. © 2001 Cancer Research Campaign www.bjcancer.com
format Text
id pubmed-2363635
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23636352009-09-10 Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas Masaki, T Matsuoka, H Sugiyama, M Abe, N Goto, A Sakamoto, A Atomi, Y Br J Cancer Regular Article Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. 38 early invasive colorectal carcinomas treated by local excision or radical surgery were examined. Tumour budding was evaluated as the number of dedifferentiation units along the entire invasive margin. Matrilysin protein levels were determined using immunohistochemical study. Univariate analysis showed that matrilysin expression alone was significantly associated with distant metastasis (P= 0.0339), and both tumour budding and matrilysin expression were significantly associated with adverse outcome (P= 0.0005, 0.0341). Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with either distant metastasis or adverse outcome. Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcome, although the significance of matrilysin expression was marginal (P= 0.0488). Tumour budding at the invasive margin and matrilysin expression are more useful in identifying high-risk groups for adverse outcome in patients with early invasive colorectal carcinomas. © 2001 Cancer Research Campaign www.bjcancer.com Nature Publishing Group 2001-05 /pmc/articles/PMC2363635/ /pubmed/11355941 http://dx.doi.org/10.1054/bjoc.2001.1790 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Masaki, T
Matsuoka, H
Sugiyama, M
Abe, N
Goto, A
Sakamoto, A
Atomi, Y
Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title_full Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title_fullStr Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title_full_unstemmed Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title_short Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
title_sort matrilysin (mmp-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363635/
https://www.ncbi.nlm.nih.gov/pubmed/11355941
http://dx.doi.org/10.1054/bjoc.2001.1790
work_keys_str_mv AT masakit matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT matsuokah matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT sugiyamam matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT aben matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT gotoa matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT sakamotoa matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas
AT atomiy matrilysinmmp7asasignificantdeterminantofmalignantpotentialofearlyinvasivecolorectalcarcinomas