Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with con...

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Autores principales: Roy, H K, Karoski, W J, Ratashak, A, Smyrk, T C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363636/
https://www.ncbi.nlm.nih.gov/pubmed/11355956
http://dx.doi.org/10.1054/bjoc.2001.1807
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author Roy, H K
Karoski, W J
Ratashak, A
Smyrk, T C
author_facet Roy, H K
Karoski, W J
Ratashak, A
Smyrk, T C
author_sort Roy, H K
collection PubMed
description Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. © 2001 Cancer Research Campaign www.bjcancer.com
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spelling pubmed-23636362009-09-10 Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation Roy, H K Karoski, W J Ratashak, A Smyrk, T C Br J Cancer Regular Article Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with concomitant induction of apoptosis, suggesting a potential mechanism for colon cancer chemoprevention. © 2001 Cancer Research Campaign www.bjcancer.com Nature Publishing Group 2001-05 /pmc/articles/PMC2363636/ /pubmed/11355956 http://dx.doi.org/10.1054/bjoc.2001.1807 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Roy, H K
Karoski, W J
Ratashak, A
Smyrk, T C
Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title_full Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title_fullStr Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title_full_unstemmed Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title_short Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
title_sort chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and bcl-2 downregulation
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363636/
https://www.ncbi.nlm.nih.gov/pubmed/11355956
http://dx.doi.org/10.1054/bjoc.2001.1807
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AT ratashaka chemopreventionofintestinaltumorigenesisbynabumetoneinductionofapoptosisandbcl2downregulation
AT smyrktc chemopreventionofintestinaltumorigenesisbynabumetoneinductionofapoptosisandbcl2downregulation

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