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Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation

Treatment of MIN mice with the nonsteroidal anti-inflammatory drug, nabumetone, resulted in a dose-dependent suppression of intestinal tumorigenesis. In both the uninvolved MIN mouse colonic epithelium and HT-29 colon cancer cells, nabumetone downregulated the anti-apoptotic protein, Bcl-2, with con...

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Detalles Bibliográficos
Autores principales:	Roy, H K, Karoski, W J, Ratashak, A, Smyrk, T C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363636/ https://www.ncbi.nlm.nih.gov/pubmed/11355956 http://dx.doi.org/10.1054/bjoc.2001.1807

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