Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental fo...

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Detalles Bibliográficos
Autores principales: Colella, G, Pennati, M, Bearzatto, A, Leone, R, Colangelo, D, Manzotti, C, Daidone, M G, Zaffaroni, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363643/
https://www.ncbi.nlm.nih.gov/pubmed/11355952
http://dx.doi.org/10.1054/bjoc.2001.1751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363643/
https://www.ncbi.nlm.nih.gov/pubmed/11355952
http://dx.doi.org/10.1054/bjoc.2001.1751

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