Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway

Over-expression of truncated epidermal growth factor receptor (EGFR) occurs in a variety of malignancies including glioblastoma multiforme, breast and lung cancer. The truncation deletes an extracellular domain and results in constitutive activation of the receptor. NIH3T3 cells were transfected wit...

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Detalles Bibliográficos
Autores principales: Clarke, K, Smith, K, Gullick, W J, Harris, A L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363647/
https://www.ncbi.nlm.nih.gov/pubmed/11355942
http://dx.doi.org/10.1054/bjoc.2001.1805

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