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Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species

Resistance to apoptosis is a major obstacle preventing effective therapy for malignancy. Mitochondria localized anti-death proteins of the Bcl-2 family play a central role in inhibiting apoptosis and therefore present valid targets for novel therapy. The peripheral benzodiazepine receptor (PBR) shar...

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Detalles Bibliográficos
Autores principales:	Fennell, D A, Corbo, M, Pallaska, A, Cotter, F E
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363650/ https://www.ncbi.nlm.nih.gov/pubmed/11355954 http://dx.doi.org/10.1054/bjoc.2001.1788

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