Cargando…
Birth order, family size, and the risk of cancer in young and middle-aged adults
We used the Swedish Family-Cancer Database to analyse the effects of birth order and family size on the risk of common cancers among offspring born over the period 1958–96. Some 1.38 million offspring up to age 55 years with 50.6 million person-years were included. Poisson regression analysis includ...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363659/ https://www.ncbi.nlm.nih.gov/pubmed/11384095 http://dx.doi.org/10.1054/bjoc.2001.1811 |
_version_ | 1782153760003325952 |
---|---|
author | Hemminki, K Mutanen, P |
author_facet | Hemminki, K Mutanen, P |
author_sort | Hemminki, K |
collection | PubMed |
description | We used the Swedish Family-Cancer Database to analyse the effects of birth order and family size on the risk of common cancers among offspring born over the period 1958–96. Some 1.38 million offspring up to age 55 years with 50.6 million person-years were included. Poisson regression analysis included age at diagnosis, birth cohort, socio-economic status and region of residence as other explanatory variables. The only significant associations were an increasing risk for breast cancer by birth order and a decreasing risk for melanoma by birth order and, particularly, by family size. When details of the women's own reproductive history were included in analysis, birth orders 5–17 showed a relative risk of 1.41. The effects on breast cancer may be mediated through increasing birth weight by birth order. For melanoma, socio-economic factors may be involved, such as limited affordability of sun tourism in large families. Testis cancer showed no significant effect and prostate cancer was excluded from analysis because of the small number of cases. © 2001 Cancer Research Campaign http://www.bjcancer.com |
format | Text |
id | pubmed-2363659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23636592009-09-10 Birth order, family size, and the risk of cancer in young and middle-aged adults Hemminki, K Mutanen, P Br J Cancer Regular Article We used the Swedish Family-Cancer Database to analyse the effects of birth order and family size on the risk of common cancers among offspring born over the period 1958–96. Some 1.38 million offspring up to age 55 years with 50.6 million person-years were included. Poisson regression analysis included age at diagnosis, birth cohort, socio-economic status and region of residence as other explanatory variables. The only significant associations were an increasing risk for breast cancer by birth order and a decreasing risk for melanoma by birth order and, particularly, by family size. When details of the women's own reproductive history were included in analysis, birth orders 5–17 showed a relative risk of 1.41. The effects on breast cancer may be mediated through increasing birth weight by birth order. For melanoma, socio-economic factors may be involved, such as limited affordability of sun tourism in large families. Testis cancer showed no significant effect and prostate cancer was excluded from analysis because of the small number of cases. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-06 /pmc/articles/PMC2363659/ /pubmed/11384095 http://dx.doi.org/10.1054/bjoc.2001.1811 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Hemminki, K Mutanen, P Birth order, family size, and the risk of cancer in young and middle-aged adults |
title | Birth order, family size, and the risk of cancer in young and middle-aged adults |
title_full | Birth order, family size, and the risk of cancer in young and middle-aged adults |
title_fullStr | Birth order, family size, and the risk of cancer in young and middle-aged adults |
title_full_unstemmed | Birth order, family size, and the risk of cancer in young and middle-aged adults |
title_short | Birth order, family size, and the risk of cancer in young and middle-aged adults |
title_sort | birth order, family size, and the risk of cancer in young and middle-aged adults |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363659/ https://www.ncbi.nlm.nih.gov/pubmed/11384095 http://dx.doi.org/10.1054/bjoc.2001.1811 |
work_keys_str_mv | AT hemminkik birthorderfamilysizeandtheriskofcancerinyoungandmiddleagedadults AT mutanenp birthorderfamilysizeandtheriskofcancerinyoungandmiddleagedadults |