Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss

Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data pr...

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Detalles Bibliográficos
Autores principales: Cabal-Manzano, R, Bhargava, P, Torres-Duarte, A, Marshall, J, Wainer, I W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363676/
https://www.ncbi.nlm.nih.gov/pubmed/11401311
http://dx.doi.org/10.1054/bjoc.2001.1830
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author Cabal-Manzano, R
Bhargava, P
Torres-Duarte, A
Marshall, J
Bhargava, P
Wainer, I W
author_facet Cabal-Manzano, R
Bhargava, P
Torres-Duarte, A
Marshall, J
Bhargava, P
Wainer, I W
author_sort Cabal-Manzano, R
collection PubMed
description Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636762009-09-10 Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss Cabal-Manzano, R Bhargava, P Torres-Duarte, A Marshall, J Bhargava, P Wainer, I W Br J Cancer Short Communication Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-06 /pmc/articles/PMC2363676/ /pubmed/11401311 http://dx.doi.org/10.1054/bjoc.2001.1830 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Cabal-Manzano, R
Bhargava, P
Torres-Duarte, A
Marshall, J
Bhargava, P
Wainer, I W
Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title_full Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title_fullStr Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title_full_unstemmed Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title_short Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
title_sort proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363676/
https://www.ncbi.nlm.nih.gov/pubmed/11401311
http://dx.doi.org/10.1054/bjoc.2001.1830
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