Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients

In women with ovarian cancer, suppression of components of the immune system may promote tumour development. Previous studies in ovarian cancer have demonstrated that decreased expression and function of the T-cell receptor (TcR)-associated signal transducing zeta-chain correlates with deficient imm...

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Detalles Bibliográficos
Autores principales: Taylor, D D, Bender, D P, Gerçel-Taylor, Ç, Stanson, J, Whiteside, T L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363678/
https://www.ncbi.nlm.nih.gov/pubmed/11401315
http://dx.doi.org/10.1054/bjoc.2001.1847
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author Taylor, D D
Bender, D P
Gerçel-Taylor, Ç
Stanson, J
Whiteside, T L
author_facet Taylor, D D
Bender, D P
Gerçel-Taylor, Ç
Stanson, J
Whiteside, T L
author_sort Taylor, D D
collection PubMed
description In women with ovarian cancer, suppression of components of the immune system may promote tumour development. Previous studies in ovarian cancer have demonstrated that decreased expression and function of the T-cell receptor (TcR)-associated signal transducing zeta-chain correlates with deficient immune responsiveness of T cells. In this study, sera and ascitic fluids obtained from woman with advanced ovarian cancer were found to suppress the expression of TcR-associated zeta chain. This suppression of zeta chain expression was dose-dependent and was not observed with biologic fluids obtained from healthy women. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636782009-09-10 Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients Taylor, D D Bender, D P Gerçel-Taylor, Ç Stanson, J Whiteside, T L Br J Cancer Regular Article In women with ovarian cancer, suppression of components of the immune system may promote tumour development. Previous studies in ovarian cancer have demonstrated that decreased expression and function of the T-cell receptor (TcR)-associated signal transducing zeta-chain correlates with deficient immune responsiveness of T cells. In this study, sera and ascitic fluids obtained from woman with advanced ovarian cancer were found to suppress the expression of TcR-associated zeta chain. This suppression of zeta chain expression was dose-dependent and was not observed with biologic fluids obtained from healthy women. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-06 /pmc/articles/PMC2363678/ /pubmed/11401315 http://dx.doi.org/10.1054/bjoc.2001.1847 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Taylor, D D
Bender, D P
Gerçel-Taylor, Ç
Stanson, J
Whiteside, T L
Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title_full Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title_fullStr Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title_full_unstemmed Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title_short Modulation of TcR/CD3-zeta chain expression by a circulating factor derived from ovarian cancer patients
title_sort modulation of tcr/cd3-zeta chain expression by a circulating factor derived from ovarian cancer patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363678/
https://www.ncbi.nlm.nih.gov/pubmed/11401315
http://dx.doi.org/10.1054/bjoc.2001.1847
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