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Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head andeck, despite loss of heterozygosity at this locus
The human tumour suppressor gene PTEN located at 10q23 is mutated in a variety of tumour types particularly metastatic cases and in the germline of some individuals with Cowdens cancer predisposition syndrome. We have assessed the status of PTEN and associated pathways in cell lines derived from 19...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2001
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363680/ https://www.ncbi.nlm.nih.gov/pubmed/11401316 http://dx.doi.org/10.1054/bjoc.2001.1848 |