Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma

Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression of PPARγ in human hepatocellular carcinoma (HCC) and the effect of PPARγ ligands on HCC cells...

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Autores principales: Rumi, M A K, Sato, H, Ishihara, S, Kawashima, K, Hamamoto, S, Kazumori, H, Okuyama, T, Fukuda, R, Nagasue, N, Kinoshita, Y
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363681/
https://www.ncbi.nlm.nih.gov/pubmed/11401318
http://dx.doi.org/10.1054/bjoc.2001.1821
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author Rumi, M A K
Sato, H
Ishihara, S
Kawashima, K
Hamamoto, S
Kazumori, H
Okuyama, T
Fukuda, R
Nagasue, N
Kinoshita, Y
author_facet Rumi, M A K
Sato, H
Ishihara, S
Kawashima, K
Hamamoto, S
Kazumori, H
Okuyama, T
Fukuda, R
Nagasue, N
Kinoshita, Y
author_sort Rumi, M A K
collection PubMed
description Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression of PPARγ in human hepatocellular carcinoma (HCC) and the effect of PPARγ ligands on HCC cells were investigated in vitro using Hep G2, HuH-7, KYN-1 and KYN-2 cell lines. All cell lines were found to express functionally active PPARγ and a marked growth inhibition was induced by thiazolidinedione ligands troglitazone, and pioglitazone as well as with its natural ligand 15-deoxy-Δ(12,14)-prostaglandin J (2). The growth inhibitory effect was associated with a dose-dependent inhibition of DNA synthesis, cell cycle progression and α fetoprotein expression. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636812009-09-10 Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma Rumi, M A K Sato, H Ishihara, S Kawashima, K Hamamoto, S Kazumori, H Okuyama, T Fukuda, R Nagasue, N Kinoshita, Y Br J Cancer Regular Article Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression of PPARγ in human hepatocellular carcinoma (HCC) and the effect of PPARγ ligands on HCC cells were investigated in vitro using Hep G2, HuH-7, KYN-1 and KYN-2 cell lines. All cell lines were found to express functionally active PPARγ and a marked growth inhibition was induced by thiazolidinedione ligands troglitazone, and pioglitazone as well as with its natural ligand 15-deoxy-Δ(12,14)-prostaglandin J (2). The growth inhibitory effect was associated with a dose-dependent inhibition of DNA synthesis, cell cycle progression and α fetoprotein expression. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-06 /pmc/articles/PMC2363681/ /pubmed/11401318 http://dx.doi.org/10.1054/bjoc.2001.1821 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Rumi, M A K
Sato, H
Ishihara, S
Kawashima, K
Hamamoto, S
Kazumori, H
Okuyama, T
Fukuda, R
Nagasue, N
Kinoshita, Y
Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title_full Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title_fullStr Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title_full_unstemmed Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title_short Peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
title_sort peroxisome proliferator-activated receptor γ ligand-induced growth inhibition of human hepatocellular carcinoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363681/
https://www.ncbi.nlm.nih.gov/pubmed/11401318
http://dx.doi.org/10.1054/bjoc.2001.1821
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