Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl...

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Autores principales: Cuq, P, Rouquet, C, Evrard, A, Ciccolini, J, Vian, L, Cano, J-P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363689/
https://www.ncbi.nlm.nih.gov/pubmed/11401323
http://dx.doi.org/10.1054/bjoc.2001.1833
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author Cuq, P
Rouquet, C
Evrard, A
Ciccolini, J
Vian, L
Cano, J-P
author_facet Cuq, P
Rouquet, C
Evrard, A
Ciccolini, J
Vian, L
Cano, J-P
author_sort Cuq, P
collection PubMed
description The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636892009-09-10 Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase Cuq, P Rouquet, C Evrard, A Ciccolini, J Vian, L Cano, J-P Br J Cancer Regular Article The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-06 /pmc/articles/PMC2363689/ /pubmed/11401323 http://dx.doi.org/10.1054/bjoc.2001.1833 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Cuq, P
Rouquet, C
Evrard, A
Ciccolini, J
Vian, L
Cano, J-P
Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title_full Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title_fullStr Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title_full_unstemmed Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title_short Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase
title_sort fluoropyrimidine sensitivity of human mcf-7 breast cancer cells stably transfected with human uridinehosphorylase
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363689/
https://www.ncbi.nlm.nih.gov/pubmed/11401323
http://dx.doi.org/10.1054/bjoc.2001.1833
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