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Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridinehosphorylase

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl...

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Detalles Bibliográficos
Autores principales:	Cuq, P, Rouquet, C, Evrard, A, Ciccolini, J, Vian, L, Cano, J-P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363689/ https://www.ncbi.nlm.nih.gov/pubmed/11401323 http://dx.doi.org/10.1054/bjoc.2001.1833

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