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Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells

The bisindole indirubin has been described, more than 30 years ago, as being clinically active in the treatment of human chronic myelocytic leukaemia. However, the underlying mechanism of action has remained unclear. We have reported previously that indirubin and its analogues are potent and selecti...

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Detalles Bibliográficos
Autores principales:	Marko, D, Schätzle, S, Friedel, A, Genzlinger, A, Zankl, H, Meijer, L, Eisenbrand, G
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363695/ https://www.ncbi.nlm.nih.gov/pubmed/11161389 http://dx.doi.org/10.1054/bjoc.2000.1546

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