Absence of rearrangements in the BRCA2 gene in human cancers

Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and smal...

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Autores principales: Chin, S-F, Wang, Q, Puisieux, A, Caldas, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363698/
https://www.ncbi.nlm.nih.gov/pubmed/11161375
http://dx.doi.org/10.1054/bjoc.2000.1577
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author Chin, S-F
Wang, Q
Puisieux, A
Caldas, C
author_facet Chin, S-F
Wang, Q
Puisieux, A
Caldas, C
author_sort Chin, S-F
collection PubMed
description Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636982009-09-10 Absence of rearrangements in the BRCA2 gene in human cancers Chin, S-F Wang, Q Puisieux, A Caldas, C Br J Cancer Short Communication Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-01 /pmc/articles/PMC2363698/ /pubmed/11161375 http://dx.doi.org/10.1054/bjoc.2000.1577 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Chin, S-F
Wang, Q
Puisieux, A
Caldas, C
Absence of rearrangements in the BRCA2 gene in human cancers
title Absence of rearrangements in the BRCA2 gene in human cancers
title_full Absence of rearrangements in the BRCA2 gene in human cancers
title_fullStr Absence of rearrangements in the BRCA2 gene in human cancers
title_full_unstemmed Absence of rearrangements in the BRCA2 gene in human cancers
title_short Absence of rearrangements in the BRCA2 gene in human cancers
title_sort absence of rearrangements in the brca2 gene in human cancers
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363698/
https://www.ncbi.nlm.nih.gov/pubmed/11161375
http://dx.doi.org/10.1054/bjoc.2000.1577
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