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The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas

In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis. The purpose of this study was to investigate the clinical significance of CD44 in adult soft tissue sarcomas (STS). 133 STS patients with a limb or superficial trunk t...

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Autores principales: Maula, S, Huuhtanen, R L, Blomqvist, C P, Wiklund, T A, Laurila, P, Ristamäki, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363706/
https://www.ncbi.nlm.nih.gov/pubmed/11161384
http://dx.doi.org/10.1054/bjoc.2000.1590
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author Maula, S
Huuhtanen, R L
Blomqvist, C P
Wiklund, T A
Laurila, P
Ristamäki, R
author_facet Maula, S
Huuhtanen, R L
Blomqvist, C P
Wiklund, T A
Laurila, P
Ristamäki, R
author_sort Maula, S
collection PubMed
description In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis. The purpose of this study was to investigate the clinical significance of CD44 in adult soft tissue sarcomas (STS). 133 STS patients with a limb or superficial trunk tumour treated at the Helsinki University Central Hospital in 1987–1993 with a median follow-up time of 68 months were included in this study. The expression of CD44 and CD44v6 was determined immunohistochemically on paraffin-embedded tumour samples. 95% of the tumours expressed CD44 and CD44v6 was detected in 57%. Strong CD44 expression was associated with low grade (P = 0.04) and small tumour size (P = 0.02). In diploid tumours the CD44 expression was correlated with low S-phase fraction (P = 0.001). High expression of both, CD44 in general as well as that of CD44v6, predicted a higher risk for local recurrence (CD44: P = 0.01 and CD44v6: P = 0.05). Low CD44v6 content of the primary tumour correlated with poor survival (P = 0.02). Determining the expression of CD44 or CD44v6 in a primary STS could be a valuable tool for selecting the group of patients who might benefit from intensified local tumour treatment. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23637062009-09-10 The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas Maula, S Huuhtanen, R L Blomqvist, C P Wiklund, T A Laurila, P Ristamäki, R Br J Cancer Regular Article In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis. The purpose of this study was to investigate the clinical significance of CD44 in adult soft tissue sarcomas (STS). 133 STS patients with a limb or superficial trunk tumour treated at the Helsinki University Central Hospital in 1987–1993 with a median follow-up time of 68 months were included in this study. The expression of CD44 and CD44v6 was determined immunohistochemically on paraffin-embedded tumour samples. 95% of the tumours expressed CD44 and CD44v6 was detected in 57%. Strong CD44 expression was associated with low grade (P = 0.04) and small tumour size (P = 0.02). In diploid tumours the CD44 expression was correlated with low S-phase fraction (P = 0.001). High expression of both, CD44 in general as well as that of CD44v6, predicted a higher risk for local recurrence (CD44: P = 0.01 and CD44v6: P = 0.05). Low CD44v6 content of the primary tumour correlated with poor survival (P = 0.02). Determining the expression of CD44 or CD44v6 in a primary STS could be a valuable tool for selecting the group of patients who might benefit from intensified local tumour treatment. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-01 /pmc/articles/PMC2363706/ /pubmed/11161384 http://dx.doi.org/10.1054/bjoc.2000.1590 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Maula, S
Huuhtanen, R L
Blomqvist, C P
Wiklund, T A
Laurila, P
Ristamäki, R
The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title_full The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title_fullStr The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title_full_unstemmed The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title_short The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
title_sort adhesion molecule cd44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363706/
https://www.ncbi.nlm.nih.gov/pubmed/11161384
http://dx.doi.org/10.1054/bjoc.2000.1590
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