Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer

We assessed the relative expression of oestrogen receptor (ER)α and oestrogen receptor (ER)β mRNAs in 36 human endometrial cancers using a multiplex polymerase chain reaction (PCR). To determine whether or not the expression of ER subtypes in endometrial cancers is associated with clinicopathologica...

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Autores principales: Takama, F, Kanuma, T, Wang, D, Kagami, I, Mizunuma, H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363767/
https://www.ncbi.nlm.nih.gov/pubmed/11207052
http://dx.doi.org/10.1054/bjoc.2000.1589
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author Takama, F
Kanuma, T
Wang, D
Kagami, I
Mizunuma, H
author_facet Takama, F
Kanuma, T
Wang, D
Kagami, I
Mizunuma, H
author_sort Takama, F
collection PubMed
description We assessed the relative expression of oestrogen receptor (ER)α and oestrogen receptor (ER)β mRNAs in 36 human endometrial cancers using a multiplex polymerase chain reaction (PCR). To determine whether or not the expression of ER subtypes in endometrial cancers is associated with clinicopathological parameters, we examined correlations between ER subtypes and age, tumour grade and depth of myometrial invasion. Using multiple regression analysis, myometrial invasion showed a significant correlation with ER-β: ER-α ratio (r = 0.54, P = 0.0007). The ER-β:ER-α ratio was high in advanced invasive carcinoma. Western blotting analysis showed that ER-β proteins were highly expressed in comparison with ER-α proteins in endometrial cancer with severe myometrial invasion. Our results suggest that ER-β is important in the progression of myometrial invasion. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23637672009-09-10 Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer Takama, F Kanuma, T Wang, D Kagami, I Mizunuma, H Br J Cancer Regular Article We assessed the relative expression of oestrogen receptor (ER)α and oestrogen receptor (ER)β mRNAs in 36 human endometrial cancers using a multiplex polymerase chain reaction (PCR). To determine whether or not the expression of ER subtypes in endometrial cancers is associated with clinicopathological parameters, we examined correlations between ER subtypes and age, tumour grade and depth of myometrial invasion. Using multiple regression analysis, myometrial invasion showed a significant correlation with ER-β: ER-α ratio (r = 0.54, P = 0.0007). The ER-β:ER-α ratio was high in advanced invasive carcinoma. Western blotting analysis showed that ER-β proteins were highly expressed in comparison with ER-α proteins in endometrial cancer with severe myometrial invasion. Our results suggest that ER-β is important in the progression of myometrial invasion. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-02 /pmc/articles/PMC2363767/ /pubmed/11207052 http://dx.doi.org/10.1054/bjoc.2000.1589 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Takama, F
Kanuma, T
Wang, D
Kagami, I
Mizunuma, H
Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title_full Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title_fullStr Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title_full_unstemmed Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title_short Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
title_sort oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363767/
https://www.ncbi.nlm.nih.gov/pubmed/11207052
http://dx.doi.org/10.1054/bjoc.2000.1589
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AT kagamii oestrogenreceptorbexpressionanddepthofmyometrialinvasioninhumanendometrialcancer
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