Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia

Macrophages can account for up to 50% of tumour mass and secrete many angiogenic factors. Furthermore, tumour hypoxia is thought to play a major role in the activation of macrophages and the regulation of angiogenesis. In this paper, we demonstrate a strong correlation between hypoxia and the recrui...

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Autores principales: Collingridge, D R, Hill, S A, Chaplin, D J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363803/
https://www.ncbi.nlm.nih.gov/pubmed/11237382
http://dx.doi.org/10.1054/bjoc.2000.1650
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author Collingridge, D R
Hill, S A
Chaplin, D J
author_facet Collingridge, D R
Hill, S A
Chaplin, D J
author_sort Collingridge, D R
collection PubMed
description Macrophages can account for up to 50% of tumour mass and secrete many angiogenic factors. Furthermore, tumour hypoxia is thought to play a major role in the activation of macrophages and the regulation of angiogenesis. In this paper, we demonstrate a strong correlation between hypoxia and the recruitment of immune cells binding to IgG in 8 experimental tumours. We provide evidence that IgG binding immune cells in 3 tumour lines are predominately composed of macrophages. Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23638032009-09-10 Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia Collingridge, D R Hill, S A Chaplin, D J Br J Cancer Regular Article Macrophages can account for up to 50% of tumour mass and secrete many angiogenic factors. Furthermore, tumour hypoxia is thought to play a major role in the activation of macrophages and the regulation of angiogenesis. In this paper, we demonstrate a strong correlation between hypoxia and the recruitment of immune cells binding to IgG in 8 experimental tumours. We provide evidence that IgG binding immune cells in 3 tumour lines are predominately composed of macrophages. Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-03 /pmc/articles/PMC2363803/ /pubmed/11237382 http://dx.doi.org/10.1054/bjoc.2000.1650 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Collingridge, D R
Hill, S A
Chaplin, D J
Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title_full Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title_fullStr Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title_full_unstemmed Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title_short Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
title_sort proportion of infiltrating igg-binding immune cells predict for tumour hypoxia
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363803/
https://www.ncbi.nlm.nih.gov/pubmed/11237382
http://dx.doi.org/10.1054/bjoc.2000.1650
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