Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients

We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). This study investigated expression of the SART3 antigen in breast cancer to explore an appropriate molecule for use in specific immunothera...

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Autores principales: Suefuji, Y, Sasatomi, T, Shichijo, S, Nakagawa, S, Deguchi, H, Koga, T, Kameyama, T, Itoh, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363830/
https://www.ncbi.nlm.nih.gov/pubmed/11286471
http://dx.doi.org/10.1054/bjoc.2000.1690
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author Suefuji, Y
Sasatomi, T
Shichijo, S
Nakagawa, S
Deguchi, H
Koga, T
Kameyama, T
Itoh, K
author_facet Suefuji, Y
Sasatomi, T
Shichijo, S
Nakagawa, S
Deguchi, H
Koga, T
Kameyama, T
Itoh, K
author_sort Suefuji, Y
collection PubMed
description We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). This study investigated expression of the SART3 antigen in breast cancer to explore an appropriate molecule for use in specific immunotherapy of breast cancer patients. The SART3 antigen was detected in all of the breast cancer cell lines tested, 30 of 40 (75%) breast cancer tissue samples, and 0 of 3 non-tumourous breast tissue samples. SART3 derived peptides at positions 109–118 and 315–323 induced HLA-A24 restricted CTLs that reacted to breast cancer cells from the peripheral blood mononuclear cells (PBMCs) of breast cancer patients. Therefore, the SART3 antigen and its peptides could be an appropriate molecule for use in specific immunotherapy of the majority of HLA-A24-positive breast cancer patients. © 2001 Cancer Research Campaignhttp://www.bjcancer.com
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spelling pubmed-23638302009-09-10 Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients Suefuji, Y Sasatomi, T Shichijo, S Nakagawa, S Deguchi, H Koga, T Kameyama, T Itoh, K Br J Cancer Regular Article We recently reported the SART3 tumour-rejection antigen as possessing tumour epitopes capable of inducing HLA-class I-restricted cytotoxic T lymphocytes (CTLs). This study investigated expression of the SART3 antigen in breast cancer to explore an appropriate molecule for use in specific immunotherapy of breast cancer patients. The SART3 antigen was detected in all of the breast cancer cell lines tested, 30 of 40 (75%) breast cancer tissue samples, and 0 of 3 non-tumourous breast tissue samples. SART3 derived peptides at positions 109–118 and 315–323 induced HLA-A24 restricted CTLs that reacted to breast cancer cells from the peripheral blood mononuclear cells (PBMCs) of breast cancer patients. Therefore, the SART3 antigen and its peptides could be an appropriate molecule for use in specific immunotherapy of the majority of HLA-A24-positive breast cancer patients. © 2001 Cancer Research Campaignhttp://www.bjcancer.com Nature Publishing Group 2001-04 /pmc/articles/PMC2363830/ /pubmed/11286471 http://dx.doi.org/10.1054/bjoc.2000.1690 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Suefuji, Y
Sasatomi, T
Shichijo, S
Nakagawa, S
Deguchi, H
Koga, T
Kameyama, T
Itoh, K
Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title_full Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title_fullStr Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title_full_unstemmed Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title_short Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients
title_sort expression of sart3 antigen and induction of ctls by sart3-derived peptides in breast cancer patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363830/
https://www.ncbi.nlm.nih.gov/pubmed/11286471
http://dx.doi.org/10.1054/bjoc.2000.1690
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