Cargando…

The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel

Bisphosphonates are well established in the management of breast-cancer-induced bone disease. Recent studies have suggested that these compounds are effective in preventing the development of bone metastases. However, it is unclear whether this reflects an indirect effect via an inhibition of bone r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jagdev, S P, Coleman, R E, Shipman, C M, Rostami-H, A, Croucher, P I
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363858/ https://www.ncbi.nlm.nih.gov/pubmed/11308265 http://dx.doi.org/10.1054/bjoc.2001.1727

Ejemplares similares

Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction
por: Neville-Webbe, H L, et al.
Publicado: (2010)

Bisphosphonates induce apoptosis in human breast cancer cell lines
por: Senaratne, S G, et al.
Publicado: (2000)

Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management
por: Dalle Carbonare, Luca, et al.
Publicado: (2010)

Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates
por: Miller, P. D., et al.
Publicado: (2016)

The bisphosphonate zoledronic acid impairs membrane localisation and induces cytochrome c release in breast cancer cells
por: Senaratne, S G, et al.
Publicado: (2002)

The bisphosphonate zoledronic acid impairs membrane localisation and induces cytochrome c release in breast cancer cells
por: Senaratne, S G, et al.
Publicado: (2002)

Safety of Intravitreal Zoledronic Acid, an Anti-angiogenic Bisphosphonate, in a Rat Model
por: Nourinia, Ramin, et al.
Publicado: (2014)

New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
por: Denoyelle, C, et al.
Publicado: (2003)

Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid
por: Ottewell, PD, et al.
Publicado: (2008)

Platelet-Rich Plasma in Treatment of Zoledronic Acid-Induced Bisphosphonate-related Osteonecrosis of the Jaws
por: Sarkarat, Farzin, et al.
Publicado: (2014)

Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw
por: Chen, Xin, et al.
Publicado: (2021)

The impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis
por: Hadji, P., et al.
Publicado: (2012)

Serosal complications of single-agent low-dose methotrexate used in gestational trophoblastic diseases: first reported case of methotrexate-induced peritonitis
por: Sharma, S, et al.
Publicado: (1999)

Synergy between liposomal zoledronic acid and γδ T-cells in the treatment of epithelial ovarian cancer
por: Pereira, Ana Catarina Parente, et al.
Publicado: (2013)

Macrophage Depletion by Free Bisphosphonates and Zoledronate-Loaded Red Blood Cells
por: Sabatino, Raffaella, et al.
Publicado: (2014)

Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid
por: Lefley, DV, et al.
Publicado: (2008)

Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid
por: Meckel, M., et al.
Publicado: (2016)

The differential anti-tumour effects of zoledronic acid in breast cancer – evidence for a role of the activin signaling pathway
por: Wilson, Caroline, et al.
Publicado: (2015)

Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma
por: Horie, N, et al.
Publicado: (2007)

The role of bisphosphonates in breast cancer: The present and future role of bisphosphonates in the management of patients with breast cancer
por: Brown, Janet E, et al.
Publicado: (2002)

Letrozole and zoledronic acid changed signalling pathways involved in the apoptosis of breast cancer cells
por: Sheweita, Salah A., et al.
Publicado: (2020)

The bisphosphonates alendronate and zoledronate induce adaptations of aerobic metabolism in permanent human endothelial cells
por: Budzinska, Adrianna, et al.
Publicado: (2023)

Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration
por: Wardley, A, et al.
Publicado: (2005)

The evolving role of zoledronic acid in early breast cancer
por: Gnant, Michael
Publicado: (2009)

A phase II trial of paclitaxel and epirubicin in advanced breast cancer
por: Rischin, D, et al.
Publicado: (2000)

Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers
por: Almubarak, Hussain, et al.
Publicado: (2011)

A prospective Phase II study for the efficacy of radiotherapy in combination with zoledronic acid in treating painful bone metastases from gastrointestinal cancers
por: Choi, Jinhyun, et al.
Publicado: (2019)

Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis
por: Messer, Jonathan G., et al.
Publicado: (2019)

Protocol for a randomised control trial of bisphosphonate (zoledronic acid) treatment in childhood femoral head avascular necrosis due to Perthes disease
por: Jamil, Kamal, et al.
Publicado: (2017)

Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells
por: Okuno, Daisuke, et al.
Publicado: (2020)

The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer
por: Coleman, R E, et al.
Publicado: (2010)

The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells
por: Brown, Hannah K, et al.
Publicado: (2011)

The role of bisphosphonates in breast cancer: Development of bisphosphonates
por: Fleisch, Herbert
Publicado: (2002)

Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells
por: Liu, X M, et al.
Publicado: (2001)

Activation of BK(Ca) Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells
por: Ma, Yu-Guang, et al.
Publicado: (2012)

Zoledronic acid directly suppresses cell proliferation and induces apoptosis in highly tumorigenic prostate and breast cancers: Retraction
Publicado: (2015)

Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
por: Mackie, P S, et al.
Publicado: (2001)

Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer Cells
por: Li, Shaojuan, et al.
Publicado: (2011)

Dose-dense epirubicin and paclitaxel with G-CSF: a study of decreasing intervals in metastatic breast cancer
por: Lalisang, R I, et al.
Publicado: (2000)

Anti-tumour activity of bisphosphonates in preclinical models of breast cancer
por: Holen, Ingunn, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_foatktnvnd662pp9ldetlto8nc