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N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours

Abnormalities in glycosphingolipid (GSL) biosynthesis have been implicated in the oncogenesis and malignancy of brain tumours. GSLs comprise the gangliosides and the neutral GSLs and are major components of the cell surface glycocalyx. N -butyldeoxynojirimycin (N B-DNJ) is an imino sugar that inhibi...

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Detalles Bibliográficos
Autores principales:	Ranes, M K, El-Abbadi, M, Manfredi, M G, Mukherjee, P, Platt, F M, Seyfried, T N
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363859/ https://www.ncbi.nlm.nih.gov/pubmed/11308262 http://dx.doi.org/10.1054/bjoc.2000.1713

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