Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase

Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(−1)) in 1% but not in 21% oxygen induced a remarkable increase in NO...

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Detalles Bibliográficos
Autores principales: Berge, D L Van den, Ridder, M De, Verovski, V N, Janssens, M Y, Monsaert, C, Storme, G A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363861/
https://www.ncbi.nlm.nih.gov/pubmed/11308264
http://dx.doi.org/10.1054/bjoc.2000.1719
Descripción
Sumario:Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(−1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign http://www.bjcancer.com

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