Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase

Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(−1)) in 1% but not in 21% oxygen induced a remarkable increase in NO...

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Autores principales: Berge, D L Van den, Ridder, M De, Verovski, V N, Janssens, M Y, Monsaert, C, Storme, G A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363861/
https://www.ncbi.nlm.nih.gov/pubmed/11308264
http://dx.doi.org/10.1054/bjoc.2000.1719
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author Berge, D L Van den
Ridder, M De
Verovski, V N
Janssens, M Y
Monsaert, C
Storme, G A
author_facet Berge, D L Van den
Ridder, M De
Verovski, V N
Janssens, M Y
Monsaert, C
Storme, G A
author_sort Berge, D L Van den
collection PubMed
description Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(−1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23638612009-09-10 Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase Berge, D L Van den Ridder, M De Verovski, V N Janssens, M Y Monsaert, C Storme, G A Br J Cancer Regular Article Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(−1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-04 /pmc/articles/PMC2363861/ /pubmed/11308264 http://dx.doi.org/10.1054/bjoc.2000.1719 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Berge, D L Van den
Ridder, M De
Verovski, V N
Janssens, M Y
Monsaert, C
Storme, G A
Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title_full Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title_fullStr Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title_full_unstemmed Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title_short Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
title_sort chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363861/
https://www.ncbi.nlm.nih.gov/pubmed/11308264
http://dx.doi.org/10.1054/bjoc.2000.1719
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