Role of chance in familial aggregation of colorectal cancer

A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I fo...

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Detalles Bibliográficos
Autores principales: Katballe, N, Bentzen, S M, Christensen, M, Wikman, F P, Ørntoft, T, Laurberg, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363862/
https://www.ncbi.nlm.nih.gov/pubmed/11308258
http://dx.doi.org/10.1054/bjoc.2000.1717
Descripción
Sumario:A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com

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