The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway

Bleomycin is a cytotoxic antibiotic that generates DNA double-strand breaks (DSB) and DNA single-strand breaks (SSB). It is possible to introduce known quantities of bleomycin molecules into cells. Low amounts kill the cells by a slow process termed mitotic cell death, while high amounts produce a f...

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Detalles Bibliográficos
Autores principales: Tounekti, O, Kenani, A, Foray, N, Orlowski, S, Mir, L M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363894/
https://www.ncbi.nlm.nih.gov/pubmed/11336481
http://dx.doi.org/10.1054/bjoc.2001.1786

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