Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is th...

Descripción completa

Detalles Bibliográficos
Autores principales: Tejpar, S, Li, C, Yu, C, Poon, R, Denys, H, Sciot, R, Cutsem, E Van, Cassiman, J J, Alman, B A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363921/
https://www.ncbi.nlm.nih.gov/pubmed/11437409
http://dx.doi.org/10.1054/bjoc.2001.1857
Descripción
Sumario:Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.com

Ejemplares similares