Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)

Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is th...

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Autores principales: Tejpar, S, Li, C, Yu, C, Poon, R, Denys, H, Sciot, R, Cutsem, E Van, Cassiman, J J, Alman, B A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363921/
https://www.ncbi.nlm.nih.gov/pubmed/11437409
http://dx.doi.org/10.1054/bjoc.2001.1857
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author Tejpar, S
Li, C
Yu, C
Poon, R
Denys, H
Sciot, R
Cutsem, E Van
Cassiman, J J
Alman, B A
author_facet Tejpar, S
Li, C
Yu, C
Poon, R
Denys, H
Sciot, R
Cutsem, E Van
Cassiman, J J
Alman, B A
author_sort Tejpar, S
collection PubMed
description Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23639212009-09-10 Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour) Tejpar, S Li, C Yu, C Poon, R Denys, H Sciot, R Cutsem, E Van Cassiman, J J Alman, B A Br J Cancer Regular Article Aggressive fibromatosis harbours mutations resulting in β-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that β-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by β-catenin stabilization in a human neoplastic process. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-07 /pmc/articles/PMC2363921/ /pubmed/11437409 http://dx.doi.org/10.1054/bjoc.2001.1857 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Tejpar, S
Li, C
Yu, C
Poon, R
Denys, H
Sciot, R
Cutsem, E Van
Cassiman, J J
Alman, B A
Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title_full Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title_fullStr Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title_full_unstemmed Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title_short Tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
title_sort tcf-3 expression and β -catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour)
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363921/
https://www.ncbi.nlm.nih.gov/pubmed/11437409
http://dx.doi.org/10.1054/bjoc.2001.1857
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