SYT-SSX fusion genes and prognosis in synovial sarcoma

A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcript appeared to be an independent, though not reaching statistical significance (P = 0.183)...

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Autores principales: Mezzelani, A, Mariani, L, Tamborini, E, Agus, V, Riva, C, Lo Vullo, S, Fabbri, A, Stumbo, M, Azzarelli, A, Casali, P G, Gronchi, A, Sozzi, G, Pierotti, M A, Pilotti, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363950/
https://www.ncbi.nlm.nih.gov/pubmed/11720441
http://dx.doi.org/10.1054/bjoc.2001.2088
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author Mezzelani, A
Mariani, L
Tamborini, E
Agus, V
Riva, C
Lo Vullo, S
Fabbri, A
Stumbo, M
Azzarelli, A
Casali, P G
Gronchi, A
Sozzi, G
Pierotti, M A
Pilotti, S
author_facet Mezzelani, A
Mariani, L
Tamborini, E
Agus, V
Riva, C
Lo Vullo, S
Fabbri, A
Stumbo, M
Azzarelli, A
Casali, P G
Gronchi, A
Sozzi, G
Pierotti, M A
Pilotti, S
author_sort Mezzelani, A
collection PubMed
description A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcript appeared to be an independent, though not reaching statistical significance (P = 0.183), prognostic factor clearly associated with a reduced metastasis-free survival. Regarding the association between transcript type and histologic subtype we found, a borderline P value (P = 0.067) between the SYT-SSX1 transcript and the biphasic subtype which, subsequently expanding the analysis to 70 cases, turned out to be significant. However, we could not confirm the prediction value of the biphasic subtype for the presence of the SYT-SSX1 transcript since in our hands 6 out 33 (18%) biphasic tumours carried the SYT-SSX2 transcript.© 2001 Cancer Research Campaign  http://www.bjcancer.com
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spelling pubmed-23639502009-09-10 SYT-SSX fusion genes and prognosis in synovial sarcoma Mezzelani, A Mariani, L Tamborini, E Agus, V Riva, C Lo Vullo, S Fabbri, A Stumbo, M Azzarelli, A Casali, P G Gronchi, A Sozzi, G Pierotti, M A Pilotti, S Br J Cancer Regular Article A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcript appeared to be an independent, though not reaching statistical significance (P = 0.183), prognostic factor clearly associated with a reduced metastasis-free survival. Regarding the association between transcript type and histologic subtype we found, a borderline P value (P = 0.067) between the SYT-SSX1 transcript and the biphasic subtype which, subsequently expanding the analysis to 70 cases, turned out to be significant. However, we could not confirm the prediction value of the biphasic subtype for the presence of the SYT-SSX1 transcript since in our hands 6 out 33 (18%) biphasic tumours carried the SYT-SSX2 transcript.© 2001 Cancer Research Campaign  http://www.bjcancer.com Nature Publishing Group 2001-11 /pmc/articles/PMC2363950/ /pubmed/11720441 http://dx.doi.org/10.1054/bjoc.2001.2088 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Mezzelani, A
Mariani, L
Tamborini, E
Agus, V
Riva, C
Lo Vullo, S
Fabbri, A
Stumbo, M
Azzarelli, A
Casali, P G
Gronchi, A
Sozzi, G
Pierotti, M A
Pilotti, S
SYT-SSX fusion genes and prognosis in synovial sarcoma
title SYT-SSX fusion genes and prognosis in synovial sarcoma
title_full SYT-SSX fusion genes and prognosis in synovial sarcoma
title_fullStr SYT-SSX fusion genes and prognosis in synovial sarcoma
title_full_unstemmed SYT-SSX fusion genes and prognosis in synovial sarcoma
title_short SYT-SSX fusion genes and prognosis in synovial sarcoma
title_sort syt-ssx fusion genes and prognosis in synovial sarcoma
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363950/
https://www.ncbi.nlm.nih.gov/pubmed/11720441
http://dx.doi.org/10.1054/bjoc.2001.2088
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