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Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer
We attempted to investigate immunohistochemical expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PD-ECGF), c-erbB-2, matrix metalloproteinase-2 (MMP-2), and MMP-9 using surgical specimens of 119 non-small-cell lung carcin...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2001
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363988/ https://www.ncbi.nlm.nih.gov/pubmed/11742492 http://dx.doi.org/10.1054/bjoc.2001.2137 |
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author | Shou, Y Hirano, T Gong, Y Kato, Y Yoshida, K Ohira, T Ikeda, N Konaka, C Ebihara, Y Zhao, F Kato, H |
author_facet | Shou, Y Hirano, T Gong, Y Kato, Y Yoshida, K Ohira, T Ikeda, N Konaka, C Ebihara, Y Zhao, F Kato, H |
author_sort | Shou, Y |
collection | PubMed |
description | We attempted to investigate immunohistochemical expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PD-ECGF), c-erbB-2, matrix metalloproteinase-2 (MMP-2), and MMP-9 using surgical specimens of 119 non-small-cell lung carcinoma (NSCLC) cases and to evaluate the relationship between the expression levels of each molecule and clinicopathological factors or prognosis. VEGF expression levels were significantly associated with the local invasion (P = 0.0001), lymph node involvement (pN-factor) (P = 0.0019), pathological stage (p-stage) (P = 0.0027) and lymphatic permeation (P = 0.0389). PD-ECGF expression levels were associated with pN-factor (P = 0.0347). MMP-2 expression levels were associated with pN-factor (P = 0.004) and lymphatic permeation (P = 0.0056). Also, MMP-9 expression levels showed a significant correlation to local invasion (P = 0.0012), pN-factor (P = 0.0093) and p-stage (P = 0.0142). Multivariate analysis showed VEGF to be the most related to local invasion (P = 0.0084), and MMP-2 was the only factor with significant independent impact on lymphatic permeation (P = 0.0228). Furthermore, log-rank analysis showed significant association with poor survival by VEGF, bFGF, MMP-2 and MMP-9. Especially, combined overexpression of VEGF and MMP-2 revealed poor prognosis, our study might provide a basis for the better evaluation of biological characteristics and a new therapeutic strategy based on chemotherapy. © 2001 Cancer Research Campaign http://www.bjcancer.com |
format | Text |
id | pubmed-2363988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23639882009-09-10 Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer Shou, Y Hirano, T Gong, Y Kato, Y Yoshida, K Ohira, T Ikeda, N Konaka, C Ebihara, Y Zhao, F Kato, H Br J Cancer Regular Article We attempted to investigate immunohistochemical expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PD-ECGF), c-erbB-2, matrix metalloproteinase-2 (MMP-2), and MMP-9 using surgical specimens of 119 non-small-cell lung carcinoma (NSCLC) cases and to evaluate the relationship between the expression levels of each molecule and clinicopathological factors or prognosis. VEGF expression levels were significantly associated with the local invasion (P = 0.0001), lymph node involvement (pN-factor) (P = 0.0019), pathological stage (p-stage) (P = 0.0027) and lymphatic permeation (P = 0.0389). PD-ECGF expression levels were associated with pN-factor (P = 0.0347). MMP-2 expression levels were associated with pN-factor (P = 0.004) and lymphatic permeation (P = 0.0056). Also, MMP-9 expression levels showed a significant correlation to local invasion (P = 0.0012), pN-factor (P = 0.0093) and p-stage (P = 0.0142). Multivariate analysis showed VEGF to be the most related to local invasion (P = 0.0084), and MMP-2 was the only factor with significant independent impact on lymphatic permeation (P = 0.0228). Furthermore, log-rank analysis showed significant association with poor survival by VEGF, bFGF, MMP-2 and MMP-9. Especially, combined overexpression of VEGF and MMP-2 revealed poor prognosis, our study might provide a basis for the better evaluation of biological characteristics and a new therapeutic strategy based on chemotherapy. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-11 /pmc/articles/PMC2363988/ /pubmed/11742492 http://dx.doi.org/10.1054/bjoc.2001.2137 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Shou, Y Hirano, T Gong, Y Kato, Y Yoshida, K Ohira, T Ikeda, N Konaka, C Ebihara, Y Zhao, F Kato, H Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title | Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title_full | Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title_fullStr | Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title_full_unstemmed | Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title_short | Influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
title_sort | influence of angiogenetic factors and matrix metalloproteinases upon tumour progression in non-small-cell lung cancer |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363988/ https://www.ncbi.nlm.nih.gov/pubmed/11742492 http://dx.doi.org/10.1054/bjoc.2001.2137 |
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